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KMID : 1134820150440081121
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Journal of the Korean Society of Food Science and Nutrition
2015 Volume.44 No. 8 p.1121 ~ p.1127
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Inhibitory Effects of Myagropsis myagroides Ethanol Extract on 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in Mice
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Kim Koth-Bong-Woo-Ri
Kang Bo-Kyeong
Ahn Na-Kyung
Choi Yeon-Uk
Bae Nan-Young
Park Ji-Hye
Park Sun-Hee
Kim Min-Ji
Ahn Dong-Hyun
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Abstract
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This study investigated the effects of Myagropsis myagroides ethanol extract (MMEE) on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like skin lesions in BALB/c mice. The effects of MMEE on DNCB-induced BALB/c mice were evaluated by examining skin symptom severity, levels of total immunoglobulin E (IgE), tumor necrosis factor-α (TNF-α), interleukin (IL)-4, and IL-10 in serum, and levels of IL-4, IL-5, IL-13, and interferon-γ (IFN-γ) in splenocytes. MMEE significantly reduced the total clinical severity score, total IgE levels, as well as TNF-α and IL-4 production in an AD mouse model but increased IL-10 production. Production of IL-4, IL-5, and IL-13 in splenocytes was reduced by MMEE, whereas IFN-γ production increased. These results suggest that MMEE can inhibit the development of AD-like skin lesions in BALB/c mice by modulating the immune response and may be an effective potential therapeutic agent for AD.
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KEYWORD
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Myagropsis myagroides, atopic dermatitis, IgE, cytokine, DNCB
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